Interaction between biological and environmental factors
in the development of metabolic diseases

Work team

Collaborators from other institutions

Line overview

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Neurobiology of aging in the limbic system and gene therapy.

Principal Investigator
Dr. Morel, Gustavo

Interaction between biological and environmental factors in the
development of metabolic diseases.

Principal Investigator
Dr. Pellon Maison, Magali

Modulation of inflammatory response and glial reactivity
in neurodegeneration models.

Principal Investigator
Dr. Bellini, María José

● Biochemistry and Biophysics of high-density lipoproteins (HDLs), apolipoprotein A-I, and atherogenic variants.
● Effect of inhibitors with anti-atherogenic implications on the activity of the cholesterol ester transfer protein (CETP).
● Glucocorticoid action in cholesterol metabolism.

Principal Investigator
Dr. González, Marina Cecilia

● Biochemistry and molecular biology of lipids and cuticular proteins in Triatoma infestans and Aedes aegypti related to insecticide resistance and adaptation to environmental factors.
● Biological control of Triatoma infestans and Aedes aegypti using entomopathogenic fungi.

Principal Investigator
Dr. Calderón Fernández G. M.  -   Dr. Girotti Juan -   Dra. Huarte Bonnet Carla

● Effects of different insecticides on the spider Loxosceleslaeta.
Biochemical and physiological study.
● How do arachnids acclimate to cold? Adaptive homeoviscosity
and antifreeze production.

Principal Investigators
Dr. Laino, Aldana   -   Dr. Gracía, Fernando   -   Dr. Cunnimgham, Mónica

Structural and biophysical analysis of lipid-binding proteins
in helminth parasites.

Principal Investigator
Dr. Franchini, Gisela

Lipids and volatile compounds involved in communication
and interaction between insects and pathogenic fungi.

Principal Investigator
Girotti, Juan R.

Structure-function and evolution of proteins in invasive mollusks,
pests, and parasite vectors.

Principal Investigator
Dr. Heras, Horacio

Study of the composition, organization, dynamics, and homeostasis
of nuclear lipid droplet populations.

Principal Investigator
Dr. Ves-Losada, Ana

Regulation of cellular glycerolipid synthesis.

Principal Investigator
Dr. González Baró, María del Rosario

Biochemistry of lipids and cuticular proteins in insects
of sanitary and agricultural importance.

Principal Investigators
Dr. Calderón Fernández G. M.

Gene and cell therapy in experimental models of Alzheimer's disease.

Principal Investigator
Dr. Reggiani, Paula

● Genomic diagnosis and structural study of proteins involved
in amyloidosis in patients.
● Study of variants of human apolipoprotein A-I involved in amyloidosis. Structure, function, and pathogenicity.

Principal Investigator
Dr. Tricerri, María Alejandra

Role of lipids in neuronal differentiation
and neurodegenerative processes.

Principal Investigator
Dr. Falomir--Lockhart, Lisandro

Antitumor mechanisms of phytochemicals and their nanovehiculization as a strategy to develop therapeutic systems with enhanced properties.

Principal Investigator
Dr. Rodenak Kladniew, Boris

Effects of metal overloads on lipid metabolism
and oxidative stress formation.
Implications for the development of Alzheimer’s disease.

Principal Investigator
Dr. Arnal, Nathalie

Fatty acid metabolism in cell proliferation and evaluation of its potential
as a therapeutic target in cancer.

Principal Investigator
Dr. Scaglia, Natalia

● Study of the structure-function of bacterial toxins in different cell types (erythrocytes, platelets, endothelial cells, Caco cells).
● Biomedical applications with toxins (design of detection kits, development of nanosponges for treatment, and immunotoxins).

Principal Investigator
Dr. Herlax, Vanesa

Role of omega-3 fatty acids on membrane composition and structure, and their relation to neuroinflammatory response, neurodegeneration, and behavior of hypertensive rats.

Principal Investigator
Dr. Maté, Sabina

Interactions between entomopathogenic fungi and their hosts.

Principal Investigator
Dr. Huarte Bonnet, Carla

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